Products Primary Antibodies Paired Antibodies
Osteocalcin/OST Recombinant Rabbit mAb (SDT-253-35)
Catalog Number： S0B3129
- Price： $70
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Host
RabbitAntigen
Osteocalcin/OSTSynonyms
OC, Bone Gla protein (BGP)Immunogen
Synthetic PeptideAccession
P02818Clone Number
SDT-253-35Antibody Type
Recombinant mAbApplication
Sandwich ELISAReactivity
HuPurification
Protein AConcentration
2 mg/mlConjugation
UnconjugatedPhysical Appearance
LiquidStorage Buffer
PBS pH7.4, 0.03% Proclin 300Stability & Storage
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
Sandwich ELISA
N/A
Osteocalcin (OC), also known as bone gla protein (BGP), is a 49 amino acid vitamin K-dependent calcium binding protein with a molecular weight of 5.9 kDa. Carboxylated OC (Gla-OC), which is capable of binding calcium, is the active form of the protein and decarboxylated OC represents the inactive form. Gla-OC has three γ-carboxylated glutamic acid residues (Gla) at positions 17, 21, and 24 that are known to mediate strong binding to hydroxyapatite. OC synthesis is dependent on both vitamins D and K. Vitamin D directly induces OC synthesis and vitamin K stimulates the gamma-carboxylation of glutamic acid residues. During osteoclastic resorption, binding of undercarboxylated osteocalcin (Glu-OC) to bone decreases, resulting in an increase in Glu-OC level in blood and urine. P. D. Delmas and colleagues have shown that undercarboxylated OC is significantly increased in elderly women, suggesting an age-dependent impairment of OC γ-carboxylation. The presence of undercarboxylated OC in serum has also been associated with changes to the bone matrix and increased fragility.
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