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Osteocalcin/OST Recombinant Rabbit mAb (SDT-253-35)

Catalog Number: S0B3129

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Product Introduction

Product Specification
  • Host

  • Antigen

  • Synonyms

    OC, Bone Gla protein (BGP)
  • Immunogen

    Synthetic Peptide
  • Accession

  • Clone Number

  • Antibody Type

    Recombinant mAb
  • Application

    Sandwich ELISA
  • Reactivity

  • Purification

    Protein A
  • Concentration

    2 mg/ml
  • Conjugation

  • Physical Appearance

  • Storage Buffer

    PBS pH7.4, 0.03% Proclin 300
  • Stability & Storage

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

    • Sandwich ELISA

  • Osteocalcin (OC), also known as bone gla protein (BGP), is a 49 amino acid vitamin K-dependent calcium binding protein with a molecular weight of 5.9 kDa. Carboxylated OC (Gla-OC), which is capable of binding calcium, is the active form of the protein and decarboxylated OC represents the inactive form. Gla-OC has three γ-carboxylated glutamic acid residues (Gla) at positions 17, 21, and 24 that are known to mediate strong binding to hydroxyapatite. OC synthesis is dependent on both vitamins D and K. Vitamin D directly induces OC synthesis and vitamin K stimulates the gamma-carboxylation of glutamic acid residues. During osteoclastic resorption, binding of undercarboxylated osteocalcin (Glu-OC) to bone decreases, resulting in an increase in Glu-OC level in blood and urine. P. D. Delmas and colleagues have shown that undercarboxylated OC is significantly increased in elderly women, suggesting an age-dependent impairment of OC γ-carboxylation. The presence of undercarboxylated OC in serum has also been associated with changes to the bone matrix and increased fragility.

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