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产品中心 细胞因子 生长因子

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Human IGF-2 Protein, hFc tag

Insulin-like growth factor II,IGF-II,Somatomedin-A,T3M-11-derived growth factor,IGF2

价格 ￥650.00 （ 供应商现货 ： 3-5个工作日）
货号 S0A4045
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Insulin-like growth factor II, IGF-II, Somatomedin-A, T3M-11-derived growth factor, IGF2

  • Accession

    P01344

  • 表达序列

    Protein sequence (P01344, Ala25-Glu91, with N-hFc tag) AYRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSRGIVEECCFRSCDLALLETYCATPAKSE

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 34.6 kDa Observed MW: 40 kDa

  • 纯度

    ＞90% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    with N-hFc tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. It has growth-regulating, insulin-like and mitogenic activities. It is believed to be a major fetal growth factor. The major role of IGF-2 is as a growth promoting hormone during gestation. IGF-2 exerts its effects by binding to the IGF-1 receptor and to the short isoform of the insulin receptor (IR-A or exon 11-). IGF-2 may also bind to the IGF-2 receptor (also called the cation-independent mannose 6-phosphate receptor), which acts as a signalling antagonist. IGF-2 acts as a co-hormone together with both FSH and LH. IGF-2 is sometimes produced in excess in islet cell tumors and non-islet hypoglycemic cell tumors, causing hypoglycemia. Loss of imprinting of IGF-2 is a common feature in tumors seen in Beckwith-Wiedemann syndrome. As IGF-2 promotes development of fetal pancreatic beta cells, it is believed to be related to some forms of diabetes mellitus.

  • 生物活性

    • Immobilized Human IGFBP-4, His tag (Cat. No. S0A6002) at 2 μg/mL (50 μL/well) can bind Human IGF-2 Protein, hFc Tag with EC50 of 39.02-43.08 ng/ml.

  • 电泳

    • 2 μg（R: reducing conditions）

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